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Recombinant Human SET domain-containing protein 4 (SETD4)

ACP10560

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Specifications

Cat.No	ACP10560	Target Name	SETD4
Target Synonyms	SETD4; C21orf18; C21orf27; SET domain-containing protein 4; EC 2.1.1.-	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-307aa
Protein Length	Isoform 4 full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NVD3

Background Information

Uniprot Id

Q9NVD3
Target Species

Human
Target Name

SETD4
Target Full Name

SET domain-containing protein 4
Target Function

Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of proinflammatory cytokines IL6 and TNF-alpha. Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation. Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)
Target Subcellular Location

Cytoplasm, cytosol. Nucleus.
Target Protein Families

Class V-like SAM-binding methyltransferase superfamily
Target Synonyms

SETD4; C21orf18; C21orf27; SET domain-containing protein 4; EC 2.1.1.-
Target Background

Enables histone methyltransferase activity (H4-K20 specific). Involved in histone H4-K20 trimethylation. Located in cytosol and nucleus.

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Recombinant Human SET domain-containing protein 4 (SETD4)

Specifications

Immunogen Information

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