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| Cat.No | ACP22067 | Target Name | SH3PXD2B |
|---|---|---|---|
| Target Synonyms | SH3PXD2B; FAD49; KIAA1295; TKS4; SH3 and PX domain-containing protein 2B; Adapter protein HOFI; Factor for adipocyte differentiation 49; Tyrosine kinase substrate with four SH3 domains | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A1X283 |
|---|
Uniprot Id
A1X283
Target Species
Human
Target Name
SH3PXD2B
Target Full Name
SH3 and PX domain-containing protein 2B
Target Function
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
Target Involvement
Frank-Ter Haar syndrome (FTHS)
Target Subcellular Location
Cytoplasm. Cell projection, podosome.
Target Protein Families
SH3PXD2 family
Target Tissue Specificity
Expressed in fibroblasts.
Target Synonyms
SH3PXD2B; FAD49; KIAA1295; TKS4; SH3 and PX domain-containing protein 2B; Adapter protein HOFI; Factor for adipocyte differentiation 49; Tyrosine kinase substrate with four SH3 domains
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