Recombinant Human Short transient receptor potential channel 3 (TRPC3), Truncated

Uniprot Id

Q13507

Target Species

Human

Target Name

TRPC3

Target Full Name

Short transient receptor potential channel 3

Target Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.

Target Involvement

Spinocerebellar ataxia 41 (SCA41)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC3 sub-subfamily

Target Tissue Specificity

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Target Synonyms

TRPC3; TRP3; Short transient receptor potential channel 3; TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3

Target Background

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.