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Amino acids 804-916 constitute the expression domain of recombinant Human SCUBE3. The expected molecular weight for the SCUBE3 protein is calculated to be 20.2 kDa. This protein is generated in a e.coli-based system. The SCUBE3 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant SCUBE3 protein in following stages of expression and purification.Signal peptide, CUB, and EGF-like domain-containing protein 3 (SCUBE3) contains a signal peptide for secretion, as well as CUB (Complement C1r/C1s, Uegf, Bmp1) and EGF-like domains, suggesting a role in cell adhesion and signaling. SCUBE3 has been implicated in angiogenesis, where it interacts with vascular endothelial growth factor (VEGF) and modulates VEGF-mediated signaling pathways. Additionally, it has been associated with platelet function, playing a role in platelet aggregation and adhesion.
Amino acids 804-916 constitute the expression domain of recombinant Human SCUBE3. The expected molecular weight for the SCUBE3 protein is calculated to be 20.2 kDa. This protein is generated in a e.coli-based system. The SCUBE3 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant SCUBE3 protein in following stages of expression and purification.Signal peptide, CUB, and EGF-like domain-containing protein 3 (SCUBE3) contains a signal peptide for secretion, as well as CUB (Complement C1r/C1s, Uegf, Bmp1) and EGF-like domains, suggesting a role in cell adhesion and signaling. SCUBE3 has been implicated in angiogenesis, where it interacts with vascular endothelial growth factor (VEGF) and modulates VEGF-mediated signaling pathways. Additionally, it has been associated with platelet function, playing a role in platelet aggregation and adhesion.
| Cat.No | ACP00845 | Target Name | SCUBE3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 804-916aa | Mol Weight | 20.2 kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IX30 |
|---|
Uniprot Id
Q8IX30
Target Species
Human
Target Name
SCUBE3
Target Full Name
Signal peptide, CUB and EGF-like domain-containing protein 3
Target Function
Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Target Subcellular Location
Secreted. Cell surface.
Target Tissue Specificity
Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.
Target Research Area
Cardiovascular
Target Synonyms
CEGF3; CUB and EGF containing protein 3; CUB and EGF-like domain-containing protein 3; CUB domain and EGF like repeat containing 3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743; OTTHUMP00000016250; SCUB3_HUMAN; SCUBE 3; SCUBE3; Signal peptide; Signal peptide CUB and EGF like domain containing protein 3; Signal peptide CUB domain EGF like 3
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