Recombinant Human Sn1-specific diacylglycerol lipase beta (DAGLB), Truncated

Uniprot Id

Q8NCG7

Target Species

Human

Target Name

DAGLB

Target Full Name

Diacylglycerol lipase-beta

Target Function

Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

AB hydrolase superfamily, Lipase family

Target Synonyms

DAGLB; Diacylglycerol lipase-beta; DAGL-beta; DGL-beta; KCCR13L; PUFA-specific triacylglycerol lipase; Sn1-specific diacylglycerol lipase beta