Recombinant Human Sodium bicarbonate cotransporter 3 (SLC4A7), Truncated

Uniprot Id

Q9Y6M7

Target Species

Human

Target Name

SLC4A7

Target Full Name

Sodium bicarbonate cotransporter 3

Target Function

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.

Target Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell projection, stereocilium.

Target Protein Families

Anion exchanger (TC 2.A.31) family

Target Tissue Specificity

Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. Isoform 1 is expressed in skeletal muscle and heart muscle.

Target Synonyms

Bicarbonate transporter; BT; Electroneutral Na/HCO(3) cotransporter; NBC2; NBC3; S4A7; S4A7_HUMAN; SBC2; SLC4A6; Slc4a7; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Sodium bicarbonate cotransporter 3; Solute carrier family 4 member 7; Solute carrier family 4 sodium bicarbonate cotransporter member 7

Target Background

This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described.