Recombinant Human Sodium-dependent phosphate transport protein 2B (SLC34A2), Truncated

Uniprot Id

O95436

Target Species

Human

Target Name

SLC34A2

Target Full Name

Sodium-dependent phosphate transport protein 2B

Target Function

May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

Target Involvement

Pulmonary alveolar microlithiasis (PALM)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

SLC34A transporter family

Target Tissue Specificity

Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.

Target Research Area

Signal Transduction

Target Synonyms

SLC34A2; Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; NaPi3b; Sodium/phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi-2b; Solute carrier family 34 member 2

Target Background

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.