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| Cat.No | ACP12907 | Target Name | RBM17 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-401 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96I25 |
|---|
Uniprot Id
Q96I25
Target Species
Human
Target Name
RBM17
Target Full Name
Splicing factor 45
Target Function
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.
Target Subcellular Location
Nucleus.
Target Synonyms
45 kDa-splicing factor; RBM 17; Rbm17; RNA binding motif protein 17; RNA-binding motif protein 17; SPF 45; SPF45; SPF45_HUMAN; Splicing factor (45 kD); Splicing factor (45kD); Splicing factor 45; Splicing factor 45 kDa; Splicing factor 45kDa
Target Background
This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15.
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