Recombinant Human Structural maintenance of chromosomes protein 5 (SMC5), Truncated

Uniprot Id

Q8IY18

Target Species

Human

Target Name

SMC5

Target Full Name

Structural maintenance of chromosomes protein 5

Target Function

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.

Target Subcellular Location

Nucleus. Chromosome. Nucleus, PML body. Chromosome, telomere.

Target Protein Families

SMC family, SMC5 subfamily

Target Tissue Specificity

Widely expressed. Strongly expressed in testis.

Target Synonyms

SMC5; KIAA0594; SMC5L1; Structural maintenance of chromosomes protein 5; SMC protein 5; SMC-5; hSMC5

Target Background

Predicted to enable ATP binding activity. Involved in several processes, including DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Located in cell junction; chromosome; and nuclear body. Part of Smc5-Smc6 complex.