Recombinant Human Synaptic vesicle glycoprotein 2B (SV2B), Truncated

Uniprot Id

Q7L1I2

Target Species

Human

Target Name

SV2B

Target Full Name

Synaptic vesicle glycoprotein 2B

Target Function

Probably plays a role in the control of regulated secretion in neural and endocrine cells.; (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.

Target Subcellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome.

Target Protein Families

Major facilitator superfamily

Target Synonyms

SV2B; KIAA0735; Synaptic vesicle glycoprotein 2B

Target Background

This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients.