Recombinant Human T-box transcription factor TBX6 (TBX6)

Uniprot Id

O95947

Target Species

Human

Target Name

TBX6

Target Full Name

T-box transcription factor TBX6

Target Function

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.

Target Involvement

Spondylocostal dysostosis 5 (SCDO5)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus.

Target Synonyms

DFNB 67; DFNB67; SCDO5; T box 6; T box protein 6; T box transcription factor TBX 6; T box transcription factor TBX6; T-box protein 6; T-box transcription factor TBX6; Tbox 6; TBX 6; tbx6; TBX6_HUMAN

Target Background

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures.