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The recombinant Human TIGIT protein is encoded by the gene of TIGIT (22-141aa). The gene of TIGIT was cloned in a system (E.coli) that supported the expression of TIGIT and translation of messenger RNA. Modification of TIGIT by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 6xHis-SUMO tag in the production. The purity is 90% determined by SDS-PAGE.TIGIT?(VSIG9, VSTM3)?is a protein coding gene that encodes T-cell immunoreceptor with Ig and ITIM domains. According to some studies, TIGIT may have the following features.TIGIT, an inhibitory receptor expressed on lymphocytes, has recently been proposed as a major emerging target for cancer immunotherapy. TIGIT has an intrinsic suppressive function of T cells. The surface protein TIGIT inhibits T cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT is a key inhibitor of the cancer immune cycle. The immunosensor TIGIT regulates antitumor and antiviral CD8+ T cell effector functions. The TIGIT/CD226 axis regulates human T cell function. Interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. TIGIT, a new immunotherapy target, is moving from the lab to the bedside.
The recombinant Human TIGIT protein is encoded by the gene of TIGIT (22-141aa). The gene of TIGIT was cloned in a system (E.coli) that supported the expression of TIGIT and translation of messenger RNA. Modification of TIGIT by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 6xHis-SUMO tag in the production. The purity is 90% determined by SDS-PAGE.TIGIT?(VSIG9, VSTM3)?is a protein coding gene that encodes T-cell immunoreceptor with Ig and ITIM domains. According to some studies, TIGIT may have the following features.TIGIT, an inhibitory receptor expressed on lymphocytes, has recently been proposed as a major emerging target for cancer immunotherapy. TIGIT has an intrinsic suppressive function of T cells. The surface protein TIGIT inhibits T cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT is a key inhibitor of the cancer immune cycle. The immunosensor TIGIT regulates antitumor and antiviral CD8+ T cell effector functions. The TIGIT/CD226 axis regulates human T cell function. Interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. TIGIT, a new immunotherapy target, is moving from the lab to the bedside.
| Cat.No | ACP02456 | Target Name | TIGIT |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 22-141aa | Mol Weight | 26.0 kDa |
| Protein Length | Extracellular Domain | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q495A1 |
|---|
Uniprot Id
Q495A1
Target Species
Human
Target Name
TIGIT
Target Full Name
T-cell immunoreceptor with Ig and ITIM domains
Target Function
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).
Target Research Area
Immunology
Target Synonyms
DKFZp667A205; ENSMUSG00000071552; FLJ39873; RGD1563191; T cell immunoreceptor with Ig and ITIM domains; TIGIT; TIGIT_HUMAN; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM
Target Background
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
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