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| Cat.No | ACP06577 | Target Name | CD28 |
|---|---|---|---|
| Target Synonyms | CD28; T-cell-specific surface glycoprotein CD28; TP44; CD antigen CD28 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P10747 |
|---|
Uniprot Id
P10747
Target Species
Human
Target Name
CD28
Target Full Name
T-cell-specific surface glycoprotein CD28
Target Function
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface.
Target Tissue Specificity
Expressed in T-cells and plasma cells, but not in less mature B-cells.
Target Synonyms
CD28; T-cell-specific surface glycoprotein CD28; TP44; CD antigen CD28
Target Background
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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