Recombinant Human TATA-binding protein-associated factor 2N (TAF15)

Uniprot Id

Q92804

Target Species

Human

Target Name

TAF15

Target Full Name

TATA-binding protein-associated factor 2N

Target Function

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

Target Involvement

A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.

Target Subcellular Location

Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm.

Target Protein Families

RRM TET family

Target Tissue Specificity

Ubiquitous. Observed in all fetal and adult tissues.

Target Synonyms

68 kDa TATA-binding protein-associated factor; Npl3; RBP56; RBP56_HUMAN; RNA binding protein 56; RNA-binding protein 56; TAF; TAF(II)68; TAF15; TAF15 RNA polymerase II TATA box binding protein (TBP) associated factor 68kDa; TAF2N; TAFII68; TATA-binding protein-associated factor 2N

Target Background

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.