Recombinant Human Teashirt homolog 3 (TSHZ3), Truncated

Uniprot Id

Q63HK5

Target Species

Human

Target Name

TSHZ3

Target Full Name

Teashirt homolog 3

Target Function

Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter. Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation

Target Involvement

TSHZ3 haploinsufficiency due to proximal chromosome 19q13.11 deletions causes a neurodevelopmental disorder characterized by developmental delay, absent or delayed speech, intellectual disability, and autistic features. Some patients may have reanal tract abnormalities.

Target Subcellular Location

Nucleus. Cell projection, growth cone.

Target Protein Families

Teashirt C2H2-type zinc-finger protein family

Target Tissue Specificity

Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease. Expressed in the fetal neocortex.

Target Synonyms

KIAA1474; Teashirt homolog 3; TSH3; TSH3_HUMAN; TSHZ3; Zinc finger protein 537