Recombinant Human Telomere-associated protein RIF1 (RIF1), Truncated

Uniprot Id

Q5UIP0

Target Species

Human

Target Name

RIF1

Target Full Name

Telomere-associated protein RIF1

Target Function

Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs. Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase. Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Promotes NHEJ of dysfunctional telomeres

Target Subcellular Location

Nucleus. Chromosome. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle.

Target Protein Families

RIF1 family

Target Tissue Specificity

Highly expressed in testis.

Target Synonyms

DKFZp781N1478; FLJ10599; FLJ11269 ; FLJ12870; Rap1 interacting factor 1; Rap1 interacting factor 1 homolog; RAP1 interacting factor homolog ; RAP1 interacting factor homolog (yeast); Rap1-interacting factor 1 homolog; Receptor interacting factor 1; RIF 1; RIF1; RIF1 isoform 4 ; RIF1_HUMAN; Telomere associated protein RIF 1; Telomere associated protein RIF1; Telomere-associated protein RIF1; Telomeric protein RIF 1; Telomeric protein RIF1