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| Cat.No | ACP11893 | Target Name | TEX15 |
|---|---|---|---|
| Target Synonyms | TEX15; Testis-expressed protein 15; Cancer/testis antigen 42; CT42 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BXT5 |
|---|
Uniprot Id
Q9BXT5
Target Species
Human
Target Name
TEX15
Target Full Name
Testis-expressed protein 15
Target Function
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair. Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci. Not required for piRNA biosynthesis.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
TEX15 family
Target Tissue Specificity
Expressed in testis, predominantly in germ cells. Low expression, if any, in ovary. Also expressed in several cancers.
Target Synonyms
TEX15; Testis-expressed protein 15; Cancer/testis antigen 42; CT42
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