Recombinant Human Thiomorpholine-carboxylate dehydrogenase (CRYM)

Uniprot Id

Q14894

Target Species

Human

Target Name

CRYM

Target Full Name

Ketimine reductase mu-crystallin

Target Function

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.

Target Involvement

Deafness, autosomal dominant, 40 (DFNA40)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Ornithine cyclodeaminase/mu-crystallin family

Target Tissue Specificity

Expressed in neural tissue, muscle and kidney.

Target Synonyms

CRYM; CRYM_HUMAN; Crystallin mu; DFNA 40; DFNA40; Ketimine reductase; Mu crystallin homolog; Mu-crystallin homolog; NADP regulated thyroid hormone binding protein; NADP-regulated thyroid-hormone-binding protein; OTTHUMP00000115878; THBP; Thiomorpholine carboxylate dehydrogenase

Target Background

Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness.