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| Cat.No | ACP21242 | Target Name | TIPRL |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-272 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75663 |
|---|
Uniprot Id
O75663
Target Species
Human
Target Name
TIPRL
Target Full Name
TIP41-like protein
Target Function
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TIP41 family
Target Synonyms
1810011K17Rik; dJ69E11.3; MGC3794; Putative MAPK activating protein PM10; Putative MAPK-activating protein PM10; RP1-69E11.1; Tip; TIP41; TIP41-like protein; tiprl; TIPRL_HUMAN; TOR signaling pathway regulator; TOR Signaling Pathway Regulator like; Type 2A-interacting protein
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