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| Cat.No | ACP14377 | Target Name | TNIP3 |
|---|---|---|---|
| Target Synonyms | TNIP3; ABIN3; LIND; TNFAIP3-interacting protein 3; A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; Listeria-induced gene protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-325 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96KP6 |
|---|
Uniprot Id
Q96KP6
Target Species
Human
Target Name
TNIP3
Target Full Name
TNFAIP3-interacting protein 3
Target Function
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Target Tissue Specificity
Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels
Target Synonyms
TNIP3; ABIN3; LIND; TNFAIP3-interacting protein 3; A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; Listeria-induced gene protein
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