Recombinant Human Toll-like receptor 10 (TLR10), Truncated

Uniprot Id

Q9BXR5

Target Species

Human

Target Name

TLR10

Target Full Name

Toll-like receptor 10

Target Function

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Toll-like receptor family

Target Tissue Specificity

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Target Synonyms

TLR10; UNQ315/PRO358; Toll-like receptor 10; CD antigen CD290

Target Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.