Recombinant Human TRAF3-interacting protein 1 (TRAF3IP1)

Uniprot Id

Q8TDR0

Target Species

Human

Target Name

TRAF3IP1

Target Full Name

TRAF3-interacting protein 1

Target Function

Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis.

Target Involvement

Senior-Loken syndrome 9 (SLSN9)

Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.

Target Protein Families

TRAF3IP1 family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

Interleukin 13 receptor alpha 1 binding protein 1; Interleukin-13 receptor alpha 1-binding protein 1; Microtubule interacting protein that associates with TRAF3; Microtubule-interacting protein associated with TRAF3; MIP T3; MIP-T3; MIPT3; MIPT3_HUMAN; TNF receptor associated factor 3 interacting protein 1; TRAF3-interacting protein 1; Traf3ip1

Target Background

The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9.