Recombinant Human Transcription initiation factor TFIID subunit 12 (TAF12)

Uniprot Id

Q16514

Target Species

Human

Target Name

TAF12

Target Full Name

Transcription initiation factor TFIID subunit 12

Target Function

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

Target Subcellular Location

Nucleus.

Target Protein Families

TAF12 family

Target Tissue Specificity

Ubiquitous.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

TAF12; TAF12 RNA polymerase II; TATA box binding protein (TBP)-associated factor; 20kDa; TAF12_HUMAN; TAF15; TAF2J; TAFII 20/TAFII 15; TAFII-20/TAFII-15; TAFII20 ; TAFII20/TAFII15; Transcription initiation factor TFIID 20/15 kDa subunits; Transcription initiation factor TFIID subunit 12

Target Background

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene.