Recombinant Human Transmembrane 9 superfamily member 4 (TM9SF4), Truncated

Uniprot Id

Q92544

Target Species

Human

Target Name

TM9SF4

Target Full Name

Transmembrane 9 superfamily member 4

Target Function

Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells. Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells

Target Subcellular Location

Membrane; Multi-pass membrane protein. Golgi apparatus. Early endosome.

Target Protein Families

Nonaspanin (TM9SF) (TC 9.A.2) family

Target Tissue Specificity

Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and granulocyte differentiat

Target Synonyms

KIAA0255; TM9S4_HUMAN; Tm9sf4; Transmembrane 9 superfamily member 4; Transmembrane 9 superfamily protein member 4