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| Cat.No | ACP07711 | Target Name | TMC1 |
|---|---|---|---|
| Target Synonyms | TMC1; Transmembrane channel-like protein 1; Transmembrane cochlear-expressed protein 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8TDI8 |
|---|
Uniprot Id
Q8TDI8
Target Species
Human
Target Name
TMC1
Target Full Name
Transmembrane channel-like protein 1
Target Function
Probable ion channel required for the normal function of cochlear hair cells.
Target Involvement
Deafness, autosomal dominant, 36 (DFNA36); Deafness, autosomal recessive, 7 (DFNB7)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
TMC family
Target Tissue Specificity
Detected in fetal cochlea, and at low levels in placenta and testis.
Target Synonyms
TMC1; Transmembrane channel-like protein 1; Transmembrane cochlear-expressed protein 1
Target Background
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness.
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