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Recombinant Human Transmembrane gamma-carboxyglutamic acid protein 2 (PRRG2), Truncated

ACP06395

Number
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Specifications


Cat.No ACP06395 Target NamePRRG2
Target SynonymsPRRG2; PRGP2; TMG2; Transmembrane gamma-carboxyglutamic acid protein 2; Proline-rich gamma-carboxyglutamic acid protein 2; Proline-rich Gla protein 2FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Protein LengthPartial
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDO14669
Background Information
  • Uniprot Id

    O14669

  • Target Species

    Human

  • Target Name

    PRRG2

  • Target Full Name

    Transmembrane gamma-carboxyglutamic acid protein 2

  • Target Subcellular Location

    Cell membrane; Single-pass type I membrane protein.

  • Target Tissue Specificity

    Widely expressed with highest levels in kidney. Also highly expressed in the thyroid.

  • Target Synonyms

    PRRG2; PRGP2; TMG2; Transmembrane gamma-carboxyglutamic acid protein 2; Proline-rich gamma-carboxyglutamic acid protein 2; Proline-rich Gla protein 2

  • Target Background

    The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene.

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