Recombinant Human Tryptase beta-2 (TPSB2)

Uniprot Id

P20231

Target Species

Human

Target Name

TPSB2

Target Full Name

Tryptase beta-2

Target Function

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.

Target Subcellular Location

Secreted. Note=Released from the secretory granules upon mast cell activation.

Target Protein Families

Peptidase S1 family, Tryptase subfamily

Target Research Area

Cell Biology, Biochemicals

Target Synonyms

Mast cell tryptase beta II; Mast cell tryptase beta III; TPS2; TPSB2; TRYB2_HUMAN; Tryptase beta 2 (gene/pseudogene); Tryptase beta-2; Tryptase II; Tryptase-2; TryptaseB; TryptaseC

Target Background

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.