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| Cat.No | ACP13640 | Target Name | TTLL11 |
|---|---|---|---|
| Target Synonyms | C9orf20; TTL11_HUMAN; Ttll11; Tubulin polyglutamylase TTLL11; Tubulin--tyrosine ligase-like protein 11 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-538 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NHH1 |
|---|
Uniprot Id
Q8NHH1
Target Species
Human
Target Name
TTLL11
Target Full Name
Tubulin polyglutamylase TTLL11
Target Function
Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Required for CCSAP localization to both spindle and cilia microtubules. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions
Target Subcellular Location
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton.
Target Protein Families
Tubulin--tyrosine ligase family
Target Synonyms
C9orf20; TTL11_HUMAN; Ttll11; Tubulin polyglutamylase TTLL11; Tubulin--tyrosine ligase-like protein 11
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