Recombinant Human Tubulinyl-Tyr carboxypeptidase 1 (VASH1)

Uniprot Id

Q7L8A9

Target Species

Human

Target Name

VASH1

Target Full Name

Tubulinyl-Tyr carboxypeptidase 1

Target Function

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts.

Target Subcellular Location

Cytoplasm. Secreted.

Target Protein Families

Vasohibin family

Target Tissue Specificity

Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.

Target Research Area

Cardiovascular

Target Synonyms

KIAA1036; VASH; VASH1; VASH1_HUMAN; Vasohibin 1; Vasohibin-1

Target Background

Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis.