Recombinant Human Tudor and KH domain-containing protein (TDRKH)

Uniprot Id

Q9Y2W6

Target Species

Human

Target Name

TDRKH

Target Full Name

Tudor and KH domain-containing protein

Target Function

Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.

Target Subcellular Location

Cytoplasm. Mitochondrion.

Target Protein Families

Tdrkh family

Target Synonyms

2700091C21Rik; Putative RNA binding protein; RGD1311196; RP11-98D18.8; TDRD2; TDRD7; Tdrkh; TDRKH_HUMAN; Tudor and KH domain containing; Tudor and KH domain-containing protein; tudor domain containing 2; Tudor domain-containing protein 2

Target Background

Predicted to enable RNA binding activity. Predicted to be involved in fertilization; gamete generation; and piRNA metabolic process. Predicted to be located in mitochondrion; pi-body; and piP-body.