Recombinant Human Tudor domain-containing protein 1 (TDRD1), Truncated

Uniprot Id

Q9BXT4

Target Species

Human

Target Name

TDRD1

Target Full Name

Tudor domain-containing protein 1

Target Function

Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.

Target Subcellular Location

Cytoplasm.

Target Protein Families

TDRD1 family

Target Tissue Specificity

Testis and ovary specific. Also expressed in several cancers.

Target Synonyms

Cancer/testis antigen 41.1; CT41.1; FLJ21082; MTR 1; TDRD 1; tdrd1; TDRD1_HUMAN; Tudor domain containing 1; Tudor domain containing protein 1; Tudor domain-containing protein 1

Target Background

This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors.