Recombinant Human Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), Truncated

Uniprot Id

Q9NS68

Target Species

Human

Target Name

TNFRSF19

Target Full Name

Tumor necrosis factor receptor superfamily member 19

Target Function

Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Target Synonyms

AL023044; AW123854; TAJ alpha; TAJ; TAJ-alpha; TNFRSF19; TNFRSF19 tumor necrosis factor receptor superfamily, member 19; TNR19_HUMAN; Toxicity and JNK inducer; TRADE; TROY; Tumor necrosis factor receptor superfamily member 19; UNQ1888/PRO4333

Target Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.