Recombinant Human Tumor necrosis factor receptor superfamily member 19L (RELT), Truncated

Uniprot Id

Q969Z4

Target Species

Human

Target Name

RELT

Target Full Name

Tumor necrosis factor receptor superfamily member 19L

Target Function

May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region.

Target Protein Families

RELT family

Target Tissue Specificity

Spleen, lymph node, brain, breast and peripheral blood leukocytes (at protein level). Expressed highly in bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in kidney and pancreas.

Target Research Area

Signal Transduction

Target Synonyms

Receptor expressed in lymphoid tissues; Relt; TNFRSF19L; TR19L_HUMAN; Tumor necrosis factor receptor superfamily member 19L

Target Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.