Recombinant Human Type-2 angiotensin II receptor (AGTR2)

Uniprot Id

P50052

Target Species

Human

Target Name

AGTR2

Target Full Name

Type-2 angiotensin II receptor

Target Function

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.

Target Research Area

Cardiovascular

Target Synonyms

AGTR 2; Agtr2; AGTR2_HUMAN; angiotensin II receptor type 2; Angiotensin II type-2 receptor; Angiotensin receptor 2; AT 2; AT2; ATGR 2; ATGR2; MRX 88; MRX88; Type 2 angiotensin II receptor; Type-2 angiotensin II receptor

Target Background

The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients.