Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 (USP20), Truncated

Cat.No	ACP09642	Target Name	USP20
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09642

Target Name

USP20

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y2K6

Background Information

Uniprot Id

Q9Y2K6
Target Species

Human
Target Name

USP20
Target Full Name

Ubiquitin carboxyl-terminal hydrolase 20
Target Function

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Target Subcellular Location

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
Target Protein Families

Peptidase C19 family, USP20/USP33 subfamily
Target Synonyms

Deubiquitinating enzyme 20; hVDU2; KIAA1003; LSFR 3A; LSFR3A; pVHL interacting deubiquitinating enzyme 2; Ubiquitin carboxyl terminal hydrolase 20; Ubiquitin carboxyl-terminal hydrolase 20; ubiquitin specific peptidase 20; Ubiquitin specific processing protease 20; Ubiquitin specific protease 20; Ubiquitin thioesterase 20; Ubiquitin thiolesterase 20; Ubiquitin-specific-processing protease 20; UBP20_HUMAN; USP 20; USP20; VDU 2; VDU2; VHL interacting deubiquitinating enzyme 2; VHL-interacting deubiquitinating enzyme 2

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 (USP20), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 (USP20), Truncated Now

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