Recombinant Human Ubiquitin carboxyl-terminal hydrolase 47 (USP47), Truncated

Uniprot Id

Q96K76

Target Species

Human

Target Name

USP47

Target Full Name

Ubiquitin carboxyl-terminal hydrolase 47

Target Function

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Peptidase C19 family

Target Tissue Specificity

Expressed in skeletal muscle, heart and testis.

Target Synonyms

Deubiquitinating enzyme 47; TFRP; Trf TATA binding protein related factor proximal homolog; Trf TATA binding protein related factor proximal homolog Drosophila; Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin specific peptidase 47; Ubiquitin specific processing protease 47; Ubiquitin specific protease 47; Ubiquitin thioesterase 47; Ubiquitin thiolesterase 47; Ubiquitin-specific-processing protease 47; UBP47_HUMAN; USP47

Target Background

Enables WD40-repeat domain binding activity and thiol-dependent deubiquitinase. Involved in several processes, including monoubiquitinated protein deubiquitination; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm. Part of SCF ubiquitin ligase complex.