Recombinant Human Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6)

Uniprot Id

O14933

Target Species

Human

Target Name

UBE2L6

Target Full Name

Ubiquitin/ISG15-conjugating enzyme E2 L6

Target Function

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Target Protein Families

Ubiquitin-conjugating enzyme family

Target Tissue Specificity

Present in natural killer cells (at protein level).

Target Synonyms

MGC40331; Retinoic acid induced gene B protein; Retinoic acid-induced gene B protein; RIG B; RIG-B; UB2L6_HUMAN; UBCH 8; UbcH8; UBE2L6; Ubiquitin carrier protein; Ubiquitin carrier protein L6; Ubiquitin conjugating enzyme E2L 6; Ubiquitin protein ligase; Ubiquitin protein ligase L6; Ubiquitin-protein ligase L6; Ubiquitin/ISG15 conjugating enzyme E2 L6; Ubiquitin/ISG15-conjugating enzyme E2 L6

Target Background

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.