Recombinant Human Ubiquitin thioesterase OTUB2 (OTUB2)

Uniprot Id

Q96DC9

Target Species

Human

Target Name

OTUB2

Target Full Name

Ubiquitin thioesterase OTUB2

Target Function

Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.

Target Protein Families

Peptidase C65 family

Target Tissue Specificity

Widely expressed. Expressed at higher level in brain.

Target Synonyms

C14orf137 ; Deubiquitinating enzyme OTUB2; FLJ21916; MGC3102; OTB2 ; OTU domain containing ubiquitin aldehyde binding protein 2; OTU domain, ubiquitin aldehyde binding 2; OTU domain-containing ubiquitin aldehyde-binding protein 2; OTU2 ; Otub2; OTUB2_HUMAN; Otubain 2; Otubain-2; Ubiquitin specific processing protease OTUB2; Ubiquitin specific protease otubain 2; Ubiquitin thioesterase OTUB2; Ubiquitin-specific-processing protease OTUB2

Target Background

This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain.