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Recombinant Human UDP-glucuronosyltransferase 1A5 (UGT1A5)

ACP02196

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Specifications

Cat.No	ACP02196	Target Name	UGT1A5
Target Synonyms	UGT1A5;UDP-glucuronosyltransferase 1-5;UDPGT 1-5;UGT1-05;UDP-glucuronosyltransferase 1-E;UGT-1E;UGT1E	Form	Liquid or Lyophilized powder
Expression System	in vitro E.coli expression system	Expression Range	29-534aa
Mol Weight	58.6 kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P35504

Background Information

Uniprot Id

P35504
Target Species

Human
Target Name

UGT1A5
Target Full Name

UDP-glucuronosyltransferase 1A5
Target Function

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II.; Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Protein Families

UDP-glycosyltransferase family
Target Tissue Specificity

Isoform 1 and isoform 2 are expressed in colon and small intestine. Neither isoform is expressed in liver, kidney or esophagus.
Target Research Area

Metabolism
Target Synonyms

UGT1A5; GNT1; UGT1; UDP-glucuronosyltransferase 1A5; UGT1A5; UDP-glucuronosyltransferase 1-5; UDPGT 1-5; UGT1*5; UGT1-05; UGT1.5; UDP-glucuronosyltransferase 1-E; UGT-1E; UGT1E

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Recombinant Human UDP-glucuronosyltransferase 1A5 (UGT1A5)

Specifications

Immunogen Information

Inquire Recombinant Human UDP-glucuronosyltransferase 1A5 (UGT1A5) Now

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