Recombinant Human UPF0172 protein FAM158A (FAM158A)

Uniprot Id

Q9Y3B6

Target Species

Human

Target Name

EMC9

Target Full Name

ER membrane protein complex subunit 9

Target Function

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).

Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

EMC8/EMC9 family

Target Research Area

Signal Transduction

Target Synonyms

EMC9; C14orf122; FAM158A; CGI-112; ER membrane protein complex subunit 9; Protein FAM158A