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Recombinant Human PLAUR is an E.coli?cell-expressed protein (Full Length of Mature Protein). E.coli?expression systems are popular because bacteria are easy to culture, grow fast and produce high yields of recombinant protein. Traditional strategies for Human PLAUR recombinant protein expression involve transforming the recombinant plasmid into the E. coli host. The cells were directly replicated, transcribed and translated, and IPTG was added to express the desired protein. Typically, the cells are then lysed to extract the expressed protein for subsequent purification. Also, many proteins become insoluble as inclusion bodies that are very difficult to recover, so mild conditions and subsequent cumbersome protein-refolding procedures are used to ensure the final provided protein is soluble.PLAUR (also known as MO3 or UPAR) is a gene that encodes a protein named urokinase plasminogen activator surface receptor (short name is U-PAR or uPAR). The protein encoded by this gene, also called monocyte activation antigen Mo3 or CD87, is a glycosylphosphatidylinositol-anchored glycoprotein and cell surface receptor specific to the urokinase plasminogen activator (uPA) and is a promoter of plasmin activation. In addition to coagulation and fibrinolysis, uPAR is also involved in processes such as cell migration, cell cycle regulation, and cell adhesion, thereby participating in various disease processes such as tumour invasion and inflammation.
Recombinant Human PLAUR is an E.coli?cell-expressed protein (Full Length of Mature Protein). E.coli?expression systems are popular because bacteria are easy to culture, grow fast and produce high yields of recombinant protein. Traditional strategies for Human PLAUR recombinant protein expression involve transforming the recombinant plasmid into the E. coli host. The cells were directly replicated, transcribed and translated, and IPTG was added to express the desired protein. Typically, the cells are then lysed to extract the expressed protein for subsequent purification. Also, many proteins become insoluble as inclusion bodies that are very difficult to recover, so mild conditions and subsequent cumbersome protein-refolding procedures are used to ensure the final provided protein is soluble.PLAUR (also known as MO3 or UPAR) is a gene that encodes a protein named urokinase plasminogen activator surface receptor (short name is U-PAR or uPAR). The protein encoded by this gene, also called monocyte activation antigen Mo3 or CD87, is a glycosylphosphatidylinositol-anchored glycoprotein and cell surface receptor specific to the urokinase plasminogen activator (uPA) and is a promoter of plasmin activation. In addition to coagulation and fibrinolysis, uPAR is also involved in processes such as cell migration, cell cycle regulation, and cell adhesion, thereby participating in various disease processes such as tumour invasion and inflammation.
| Cat.No | ACP03946 | Target Name | PLAUR |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 23-305aa | Mol Weight | 58.5kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q03405 |
|---|
Uniprot Id
Q03405
Target Species
Human
Target Name
PLAUR
Target Full Name
Urokinase plasminogen activator surface receptor
Target Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Target Subcellular Location
Cell membrane. Cell projection, invadopodium membrane.; [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 2]: Secreted.
Target Tissue Specificity
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Target Research Area
Cancer
Target Synonyms
CD 87; CD87; CD87 antigen; MO 3; MO3; Monocyte activation antigen Mo3; Plasminogen activator receptor urokinase; Plasminogen activator urokinase receptor; PLAUR; U PAR; u plasminogen activator receptor; U-PAR; u-plasminogen activator receptor form 2; UPA receptor; uPAR; UPAR_HUMAN; Urinary plasminogen activator receptor; URKR; Urokinase plasminogen activator receptor; Urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor
Target Background
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
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