Recombinant Human V-set and immunoglobulin domain-containing protein 1 (VSIG1), Truncated

Uniprot Id

Q86XK7

Target Species

Human

Target Name

VSIG1

Target Full Name

V-set and immunoglobulin domain-containing protein 1

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Detected only in stomach mucosa and testis, and to a much lesser level in pancreas (at protein level). Detected in gastric cancers (31%), esophageal carcinomas (50%) and ovarian cancers (23%).

Target Research Area

Immunology

Target Synonyms

1700062D20Rik; Cell surface A33 antigen; ChT1 thymocyte antigen; dJ889N15.1; Glycoprotein A34; GPA34; MGC44287; OTTHUMP00000023820; V set and immunoglobulin domain containing; V-set and immunoglobulin domain containing 1; V-set and immunoglobulin domain-containing protein 1; VSIG1; VSIG1_HUMAN

Target Background

This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.