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| Cat.No | ACP13133 | Target Name | VPS52 |
|---|---|---|---|
| Target Synonyms | VPS52; SACM2LVacuolar protein sorting-associated protein 52 homolog; SAC2 suppressor of actin mutations 2-like protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-723 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N1B4 |
|---|
Uniprot Id
Q8N1B4
Target Species
Human
Target Name
VPS52
Target Full Name
Vacuolar protein sorting-associated protein 52 homolog
Target Function
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
Target Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Recycling endosome.
Target Protein Families
VPS52 family
Target Synonyms
VPS52; SACM2LVacuolar protein sorting-associated protein 52 homolog; SAC2 suppressor of actin mutations 2-like protein
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