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A truncated version of Vascular cell adhesion protein 1 (VCAM1) encoding the extracellular domain and carrying a 6xHis-tag at the N-terminus was produced in the yeast. The resulting protein is a partial-length VCAM1 protein. It contains aa of 25-698 of the human VCAM1 protein. It was purified by SDS-PAGE and reached up to 90% in purity. On the reducing SDS-PAEG gel, this VCAM1 protein migrated on the molecular weight band of about 66-116 kDa. In addition to producing specific antibodies, the recombinant VCAM1 protein could also be used in the studies of VACM-related immunology or signal transduction. VCAM-1, or called CD106, is a glycoprotein primarily expressed in endothelial cells. Pro-inflammatory cytokines, ROS, high glucose concentration, oxidized low-density lipoprotein, shear stress, and toll-like receptor agonists, can induce the expression of VCAM-1. VCAM-1 participates in the modulation of inflammation-associated vascular adhesion and the transendothelial migration of leukocytes. Recent studies show the close link of VCAM-1 to the progression of various immunological disorders, such as asthma, rheumatoid arthritis, transplant rejection, and cancer.
A truncated version of Vascular cell adhesion protein 1 (VCAM1) encoding the extracellular domain and carrying a 6xHis-tag at the N-terminus was produced in the yeast. The resulting protein is a partial-length VCAM1 protein. It contains aa of 25-698 of the human VCAM1 protein. It was purified by SDS-PAGE and reached up to 90% in purity. On the reducing SDS-PAEG gel, this VCAM1 protein migrated on the molecular weight band of about 66-116 kDa. In addition to producing specific antibodies, the recombinant VCAM1 protein could also be used in the studies of VACM-related immunology or signal transduction.
VCAM-1, or called CD106, is a glycoprotein primarily expressed in endothelial cells. Pro-inflammatory cytokines, ROS, high glucose concentration, oxidized low-density lipoprotein, shear stress, and toll-like receptor agonists, can induce the expression of VCAM-1. VCAM-1 participates in the modulation of inflammation-associated vascular adhesion and the transendothelial migration of leukocytes. Recent studies show the close link of VCAM-1 to the progression of various immunological disorders, such as asthma, rheumatoid arthritis, transplant rejection, and cancer.
| Cat.No | ACP04814 | Target Name | VCAM1 |
|---|---|---|---|
| Target Synonyms | CD106; CD106 Antigen; INCAM 100; INCAM-100; L1CAM; MGC99561; V-CAM 1; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; VCAM1; VCAM1_HUMAN | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 25-698aa |
| Mol Weight | 76.2kDa | Protein Length | Extracellular Domain |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P19320 |
|---|
Uniprot Id
P19320
Target Species
Human
Target Name
VCAM1
Target Full Name
Vascular cell adhesion protein 1
Target Function
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Target Research Area
Cell Adhesion
Target Synonyms
CD106; CD106 Antigen; INCAM 100; INCAM-100; L1CAM; MGC99561; V-CAM 1; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; VCAM1; VCAM1_HUMAN
Target Background
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
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