Recombinant Human Very low-density lipoprotein receptor (VLDLR), Truncated

Uniprot Id

P98155

Target Species

Human

Target Name

VLDLR

Target Full Name

Very low-density lipoprotein receptor

Target Function

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.

Target Involvement

Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1)

Target Subcellular Location

Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.

Target Tissue Specificity

Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

Target Synonyms

FLJ35024; Very low density lipoprotein receptor; Very low-density lipoprotein receptor; VLDL R; VLDL receptor; VLDL-R; VLDLR; VLDLR_HUMAN; VLDLRCH

Target Background

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.