Recombinant Human Vesicle-associated membrane protein 1 (VAMP1), Truncated

Uniprot Id

P23763

Target Species

Human

Target Name

VAMP1

Target Full Name

Vesicle-associated membrane protein 1

Target Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Target Involvement

Spastic ataxia 1, autosomal dominant (SPAX1)

Target Subcellular Location

[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.; [Isoform 2]: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.; [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein.

Target Protein Families

Synaptobrevin family

Target Tissue Specificity

Nervous system, skeletal muscle and adipose tissue.

Target Synonyms

VAMP1; SYB1; Vesicle-associated membrane protein 1; VAMP-1; Synaptobrevin-1

Target Background

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined.