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| Cat.No | ACP18346 | Target Name | WDR43 |
|---|---|---|---|
| Target Synonyms | WDR43; KIAA0007; UTP5; WD repeat-containing protein 43; U3 small nucleolar RNA-associated protein 5 homolog | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-677 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q15061 |
|---|
Uniprot Id
Q15061
Target Species
Human
Target Name
WDR43
Target Full Name
WD repeat-containing protein 43
Target Function
Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes.
Target Subcellular Location
Nucleus, nucleolus. Nucleus, nucleolus fibrillar center. Nucleus, nucleoplasm.
Target Protein Families
UTP5 family
Target Synonyms
WDR43; KIAA0007; UTP5; WD repeat-containing protein 43; U3 small nucleolar RNA-associated protein 5 homolog
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