Recombinant Human Y+L amino acid transporter 1 (SLC7A7), Truncated

Uniprot Id

Q9UM01

Target Species

Human

Target Name

SLC7A7

Target Full Name

Y+L amino acid transporter 1

Target Function

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.

Target Involvement

Lysinuric protein intolerance (LPI)

Target Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family

Target Tissue Specificity

Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, ret

Target Synonyms

LAT3; LPI; Monocyte amino acid permease 2; MOP-2; MOP2; SLC7A 7; Slc7a7; Solute carrier family 7 (cationic amino acid transporter; y+ system); member 7 ; Solute carrier family 7 member 7; y(+)L type amino acid transporter 1; y(+)L-type amino acid transporter 1; Y+L amino acid transporter 1; y+LAT-1; Y+LAT1; YLAT1_HUMAN