Recombinant Human Zinc finger and BTB domain-containing protein 20 (ZBTB20)

Uniprot Id

Q9HC78

Target Species

Human

Target Name

ZBTB20

Target Full Name

Zinc finger and BTB domain-containing protein 20

Target Function

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.

Target Involvement

Primrose syndrome (PRIMS)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver.

Target Synonyms

Dendritic derived BTB/POZ zinc finger protein; Dendritic-derived BTB/POZ zinc finger protein; DKFZp566F123; DPZF; HOF; ODA 8S; OTTHUMP00000215066; OTTHUMP00000215067; OTTHUMP00000215069; OTTHUMP00000215071; ZBT20_HUMAN; Zbtb20; zinc finger 288; zinc finger and BTB domain containing 20; Zinc finger and BTB domain-containing protein 20; Zinc finger protein 288; ZNF288

Target Background

This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.