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| Cat.No | ACP11017 | Target Name | ZCWPW1 |
|---|---|---|---|
| Target Synonyms | ZCWPW1Zinc finger CW-type PWWP domain protein 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-648 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H0M4 |
|---|
Uniprot Id
Q9H0M4
Target Species
Human
Target Name
ZCWPW1
Target Full Name
Zinc finger CW-type PWWP domain protein 1
Target Function
Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs). Essential for male fertility and spermatogenesis. Required for meiosis prophase I progression in male but not in female germ cells.
Target Subcellular Location
Nucleus. Chromosome.
Target Tissue Specificity
Testis.
Target Synonyms
ZCWPW1Zinc finger CW-type PWWP domain protein 1
Target Background
Enables methyl-CpG binding activity and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body. Predicted to be active in nucleus.
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